Background: cfDNA screening accuracy in high-risk pregnancies requires contemporary validation. Methods: Prospective study of 3,200 high-risk pregnancies undergoing cfDNA screening and confirmatory invasive testing. Sensitivity, specificity, PPV, NPV calculated for T21, T18, T13, and 45,X. Results: T21 sensitivity 99.2%, PPV 97.4%; T18 sensitivity 97.8%, PPV 89.2%; T13 sensitivity 94.3%, PPV 78.6%. Failure rate 2.1%. Turnaround time median 9 days. Conclusion: cfDNA screening demonstrates high sensitivity and PPV for common aneuploidies in high-risk pregnancies, supporting its role as primary screening strategyn
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